Atrial arrhythmogenesis and electrophysiological remodeling in hypokalaemic metabolic syndrome: the role of apamin-sensitive SK channels
Our study demonstrated that apamin-sensitive SK channels may exert an antiarrhythmic effect in a hypokalaemic heart of the MetS model. These findings underscore the importance of evaluating the potential risks associated with the use of SK channel blockers in patients with hypokalaemic MetS.
Authors
- Hsiang‐Chun Lee (ORCID: https://orcid.org/0000-0002-5877-9059)
- Shih‐Jie Jhuo (ORCID: https://orcid.org/0000-0001-8008-9671)
- Erh‐Ti Lin (ORCID: https://orcid.org/0000-0002-8242-9315)
- Po‐Chao Hsu (ORCID: https://orcid.org/0000-0001-6217-3036)
- Bin‐Nan Wu (ORCID: https://orcid.org/0000-0001-6593-5120)
- Chun‐Chieh Wu (ORCID: https://orcid.org/0000-0003-0284-3784)
- Shien‐Fong Lin (ORCID: https://orcid.org/0000-0003-1270-3961)
- Chien‐Hung Lee (ORCID: https://orcid.org/0000-0002-0988-264X)
- Pin‐Chieh Huang (ORCID: https://orcid.org/0000-0002-6871-4160)
- Chao‐Yi Chen (ORCID: https://orcid.org/0000-0002-2127-6909)
- Tien‐Chi Huang (ORCID: https://orcid.org/0000-0002-1872-4395)
- X Chen
- Wei‐Chung Tsai
- Pei‐Heng Kao (ORCID: https://orcid.org/0000-0003-0682-8418)
- Tzu-Chieh Lin (ORCID: https://orcid.org/0000-0003-0810-4907)
- Chien‐Wei Chang (ORCID: https://orcid.org/0000-0002-0336-418X)
- Yi‐Hsiung Lin (ORCID: https://orcid.org/0000-0003-2232-9037)
- I-Hsin Liu
- Ruo-Yun Shih (ORCID: https://orcid.org/0009-0000-5597-2657)
- Yandong Zheng (ORCID: https://orcid.org/0000-0003-4534-5670)
- Min-Huei Lin
- Guanlin Chen (ORCID: https://orcid.org/0009-0004-4735-0582)
- Wen‐Ter Lai
- Chia‐Hao Kuo
- Yu-Chen Feng
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
Publication Details
- Journal
- EP Europace
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/europace/euaf159
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Ministry of Science and Technology
- Kaohsiung Medical University Chung-Ho Memorial Hospital