Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease
In individuals with T2D without overt CVD, lower MFR, presence of perfusion defects, and CACS > 300 were associated with lower LVEF-reserve. Underscoring a potential role of microvascular dysfunction in subclinical systolic impairment.
Authors
- Lene Holmvang (ORCID: https://orcid.org/0000-0002-0941-378X)
- Tine W. Hansen (ORCID: https://orcid.org/0000-0003-2274-0352)
- A Chebli
- Philip Hasbak (ORCID: https://orcid.org/0000-0002-6254-6012)
- Emilie H. Zobel (ORCID: https://orcid.org/0000-0003-3318-7070)
- Mats Christian Højbjerg Lassen (ORCID: https://orcid.org/0000-0002-2255-582X)
- Allan Kofoed‐Enevoldsen (ORCID: https://orcid.org/0000-0001-7051-1381)
- Andreas Kjær (ORCID: https://orcid.org/0000-0002-2706-5547)
- Urd Kielgast (ORCID: https://orcid.org/0000-0001-9914-0676)
- Ida Kirstine Bull Rasmussen (ORCID: https://orcid.org/0000-0001-6849-763X)
- R Ripa (ORCID: https://orcid.org/0000-0003-2035-2321)
- Morten Lindhardt (ORCID: https://orcid.org/0000-0001-6063-1718)
- Tor Biering‐Sørensen (ORCID: https://orcid.org/0000-0003-4209-2778)
- Peter R Rossing (ORCID: https://orcid.org/0000-0002-1531-4294)
- Victor Wasehuus (ORCID: https://orcid.org/0000-0003-1822-8188)
- Anne-Cathrine Skriver-Møller
- Martin Bæk Blond (ORCID: https://orcid.org/0000-0002-2032-1560)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Herlev Hospital (DK)
- Bispebjerg Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Holbæk Sygehus (DK)
- Zealand University Hospital Køge (DK)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12933-025-02886-3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Boston Scientific Corporation
- Steno Diabetes Center Copenhagen
- Novo Nordisk
- Rigshospitalet
- Novo Nordisk Fonden
- Seqirus
- Sanofi Pasteur