Lineage-specific transcription factor landscape of thymic neuroendocrine tumors
This study reveals molecular heterogeneity among TNETs. Notably, ASCL1 and YAP1 co-expression characterizes all LCNEC cases, making a distinct TF landscape in high-grade TNETs.
Authors
- Takao Shigenobu
- Kaoru Kaseda (ORCID: https://orcid.org/0000-0003-3022-9060)
- Hideki Terai (ORCID: https://orcid.org/0000-0002-1118-1930)
- M. Suzuki (ORCID: https://orcid.org/0000-0002-2769-6541)
- Yutaka Kurebayashi (ORCID: https://orcid.org/0000-0003-3773-0851)
- Kyohei Masai (ORCID: https://orcid.org/0000-0003-2039-0483)
- Chihaya Maeda
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Hiroyuki Yasuda (ORCID: https://orcid.org/0000-0001-9966-8569)
- Junko Hamamoto (ORCID: https://orcid.org/0000-0002-8054-0124)
- Kazuo Nakagawa (ORCID: https://orcid.org/0000-0002-5600-2721)
- Akira Yoshizu
- Keisuke Asakura (ORCID: https://orcid.org/0000-0002-4491-3456)
- Tomohiro Imoto
- Yu Okubo (ORCID: https://orcid.org/0000-0003-4778-3762)
- Shigeki Suzuki (ORCID: https://orcid.org/0000-0002-8520-9393)
- Seiji Omura
- Masahiro Kaji
- Takahiro Suzuki (ORCID: https://orcid.org/0009-0008-0402-5906)
Institutions
- Keio University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Saiseikai Central Hospital (JP)
- Yokohama Municipal Citizen's Hospital (JP)
Publication Details
- Journal
- Lung Cancer
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.lungcan.2025.108731
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science