Divergent biological pathways distinguish community-acquired pneumonia from COVID-19 despite similar plasma cytokine profiles
This case-control study provides insights into cytokine profiles related to CAP and COVID-19 pathogenesis. Although absolute circulating cytokine levels showed no significant differences between the groups, machine learning identified a model of twelve proteins that effectively distinguished the cohorts. Gene ontology and enrichment analyses also revealed distinct dysregulated pathways with differing associations with clinical variables in each cohort. These findings underscore the complexity and variability of cytokine responses in pulmonary infections.
Authors
- Greg Haljan
- Alastair Teale
- Keith R. Walley (ORCID: https://orcid.org/0000-0003-4232-7266)
- Julia Kong
- David R. Sweet (ORCID: https://orcid.org/0000-0002-1982-2958)
- Nick Daneman (ORCID: https://orcid.org/0000-0001-8827-3764)
- Peter Birks (ORCID: https://orcid.org/0000-0002-6418-4676)
- Yves Cohen (ORCID: https://orcid.org/0000-0001-6022-9366)
- Ajit K. Karna (ORCID: https://orcid.org/0000-0002-5557-4402)
- Johann Auchabie
- Gaëtan Plantefève (ORCID: https://orcid.org/0000-0003-3070-7368)
- Karen C. Tran (ORCID: https://orcid.org/0000-0003-3220-2902)
- Sigismond Lasocki (ORCID: https://orcid.org/0000-0003-2901-4628)
- Matthew P. Cheng (ORCID: https://orcid.org/0000-0002-4867-2063)
- François Lamontagne (ORCID: https://orcid.org/0000-0002-0360-3427)
- Douglas D. Fraser (ORCID: https://orcid.org/0000-0002-5635-3791)
- Gordon D. Wood
- Daniel Ovakim
- Marine Goudelin (ORCID: https://orcid.org/0000-0001-5014-5193)
- David M. Forrest
- Joel Singer (ORCID: https://orcid.org/0000-0003-4936-4086)
- Jennifer Tsang (ORCID: https://orcid.org/0000-0002-1809-0505)
- Séverine Ansart (ORCID: https://orcid.org/0000-0002-4901-3975)
- Jean‐Marc Tadié (ORCID: https://orcid.org/0000-0002-7604-4849)
- Todd C. Lee (ORCID: https://orcid.org/0000-0002-2267-4239)
- Marie Gousseff
- Vincent Dubée (ORCID: https://orcid.org/0000-0002-9982-4741)
- Mark Daley (ORCID: https://orcid.org/0000-0002-6939-9772)
- Guillaume Géri (ORCID: https://orcid.org/0000-0002-7691-6635)
- Logan R. Van Nynatten
- Alexis F. Turgeon (ORCID: https://orcid.org/0000-0001-5675-8791)
- Brent W. Winston (ORCID: https://orcid.org/0000-0003-2993-8871)
- Neil K. J. Adhikari
- Pierre Leroy (ORCID: https://orcid.org/0000-0001-7845-6970)
- J.-P. Talarmin
- Julien Demiselle (ORCID: https://orcid.org/0000-0002-7255-1114)
- Jean‐Pierre Quenot (ORCID: https://orcid.org/0000-0003-2351-682X)
- Jean‐Paul Mira (ORCID: https://orcid.org/0000-0001-8121-3769)
- Eddy Lebas
- Ferhat Meziani
- Terry Lee (ORCID: https://orcid.org/0000-0003-2582-2337)
- James A. Russell
- Pierre Asfar
- John H. Boyd
- P Rispal
- Steve Reynolds
- Robert Fowler
- Roxane Courtois
- David Tweddell
- Boris Bienvenue
Institutions
- Western University (CA)
- St. Paul's Hospital (CA)
- Children’s Health Research Institute (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12931-025-03331-5
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Academic Medical Organization of Southwestern Ontario
- St. Paul's Foundation
- London Health Sciences Foundation
- Canadian Institutes of Health Research