ANTIBIOTIC RESISTANCE: AN OBSERVATIONAL STUDY FROM INTENSIVE CARE UNIT OF PEOPLE UNIVERSITY OF MEDICAL AND HEALTH SCIENCES, NAWAB SHAH SINDH, PAKISTAN.

Infectious diseases are very common in all age groups and intensive care units are very sensitive areas of any hospital patients are very critical and all measures are adopted to avoid any sort of contamination and transmission of infections. Despite of that infections are frequently reported from theses sensitive areas of the hospitals. This study was conducted to evaluate the common pathogens responsible for in such population of patients. Antibiotic resistance is another challenge faced by the treating physicians indoor, out door and critically ill patients so the current research work also focused on this aspect of treatment and evaluated the response of antibiotic therapy against various pathogens by assessing culture and sensitivity in the samples obtained from patients admitted in the intensive care unit of the people university of medical and health sciences shaheed Benazir Abad (Nawab Shah, Sindh). Patients were selected through purposive and consecutive sampling, blood, urine and swab samples were collected under aseptic measures from patients running fever. There were 42 such cases evaluated the mean age of the study participants was 17.38+7.13 years with the minimum age as 11 years while the maximum as 60 years. Common pathogens found on culture and sensitivity reports after 72 hours of incubation were Proteus, Klebsiella, Staphylococcus and Streptococcus. Cephalosporins, Penicillin group, Macrolides, Fluroquinolones, Linezolid, Aminoglycosides, Meropenem and Fosfomycin were the common antibiotics tested. There 26(61.90%) males and 16(38.10%) females and bacterial growth was seen in 10(23.81%) of the patients while no bacterial growth was reported for 32(76.19%) patients after an incubation of 48 hours. Proteus was found sensitive to Meropenem and Amikacin while Klebsiella was found sensitive to Fosfomycin and Imipenem.