Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis
These results suggest that levels of RIF resistance in clinical RIF-resistant M. tuberculosis isolates are ultimately determined by a combination of efflux pump activity and rpoB gene mutations.
Authors
- Jie Lei (ORCID: https://orcid.org/0000-0002-2660-2021)
- Lan Gong (ORCID: https://orcid.org/0000-0003-3136-1565)
- Li Deng (ORCID: https://orcid.org/0000-0002-1522-4184)
- Yu Yang (ORCID: https://orcid.org/0000-0002-2378-910X)
- Zhihui Liu
- Hua Li (ORCID: https://orcid.org/0000-0002-5264-4671)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1909-302X)
- Bei Xie
- Qun Niu (ORCID: https://orcid.org/0000-0003-1128-0784)
- Fanrong Meng (ORCID: https://orcid.org/0000-0001-7700-8519)
- Xiaomin Lai (ORCID: https://orcid.org/0000-0001-8226-6248)
- Ling Wu
- Junwen Gao
- Zeyou Wei
- Nan Wang (ORCID: https://orcid.org/0009-0003-9735-4314)
- Qi Wang (ORCID: https://orcid.org/0000-0003-0962-4218)
Institutions
- Sun Yat-sen University (CN)
- Center for Tuberculosis Control of Guangdong Province (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Chest Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12941-025-00816-5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China