A mouse model of E-cigarette or vaping product use-associated lung injury (EVALI) induced by nose-only exposure to aerosolized vitamin E acetate and associated macrophage dysfunction
This study established a mouse model using a nose-only VEA aerosol exposure system to examine the respiratory effects of VEA in EVALI. Our results revealed that VEA inhalation triggered acute lung injury, accompanied by early signs of airway dysfunction. The findings support the hypothesis that VEA drives EVALI pathogenesis through both direct cytotoxic effects and macrophage-mediated inflammation. Our findings offer new insights into the mechanisms of EVALI and present a valuable model for future research.
Authors
- Hanbing Hu
- Yu Dun (ORCID: https://orcid.org/0000-0003-2018-1542)
- Weichun Mo (ORCID: https://orcid.org/0000-0001-5565-160X)
- Jian Zhou (ORCID: https://orcid.org/0000-0003-4736-9457)
- Jie Shen (ORCID: https://orcid.org/0009-0000-1484-6523)
- Fuli Liu (ORCID: https://orcid.org/0000-0001-6320-5132)
- Yuedong Tang
- Xuanrong Bao
Institutions
- Shanghai University (CN)
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Zhongshan Hospital (CN)
- Shanghai Municipal Commission of Health and Family Planning (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12931-025-03343-1
- Citations
- 1
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality