Can Integra outperform local flaps in the reconstruction of face and scalp skin cancer defects?

Reconstruction of oncologic soft tissue defects with Integra is related to high graft failure rates, limiting its clinical effectiveness compared to local flaps. Surgical factors like subsequent epidermal grafting, fenestration, or antibiotic prophylaxis are likely to improve outcomes. The development of a standardized surgical approach based on randomized, prospective research is warranted, as Integra can enable the closure of large defects in medically complex patients, unsuitable for reconstruction by other methods.