Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction
Among low-risk patients with acute myocardial infarction who had undergone early complete revascularization and had completed 1 month of dual antiplatelet therapy without complications, P2Y12-inhibitor monotherapy was noninferior to continued dual antiplatelet therapy with respect to the occurrence of adverse cardiovascular and cerebrovascular events and resulted in a lower incidence of bleeding events. (Funded by MicroPort [France]; TARGET-FIRST ClinicalTrials.gov number, NCT04753749.).
Authors
- Philippe Riccini
- Jacopo Oreglia (ORCID: https://orcid.org/0000-0002-8406-7696)
- Giuseppe Tarantini (ORCID: https://orcid.org/0000-0002-5055-2917)
- Matthieu Godin
- Grégoire Rangé (ORCID: https://orcid.org/0000-0001-7073-354X)
- Maribel Madera‐Cambero
- Lionel Mangin (ORCID: https://orcid.org/0000-0001-9336-3553)
- Benjamin Honton (ORCID: https://orcid.org/0000-0003-3715-0160)
- Gilles Lemesle (ORCID: https://orcid.org/0000-0002-2917-9273)
- Farzin Beygui (ORCID: https://orcid.org/0000-0003-2170-8983)
- Juan M. Ruiz-Nodar (ORCID: https://orcid.org/0000-0002-8480-0835)
- Beatriz Vaquerizo (ORCID: https://orcid.org/0000-0002-1428-3596)
- F. De Poli (ORCID: https://orcid.org/0000-0002-4540-0329)
- David Bouchez (ORCID: https://orcid.org/0000-0003-3545-4339)
- Valeria Paradies (ORCID: https://orcid.org/0000-0003-3513-7819)
- Salvatore Brugaletta (ORCID: https://orcid.org/0000-0001-5845-1435)
- Christophe Piot (ORCID: https://orcid.org/0000-0001-7497-0294)
- Thibault Lhermusier (ORCID: https://orcid.org/0000-0002-4260-2339)
- Yann Poezevara
- Pieter C. Smits (ORCID: https://orcid.org/0000-0002-9164-720X)
- Guillaume Cayla (ORCID: https://orcid.org/0000-0002-3958-2568)
- Thomas Cuisset (ORCID: https://orcid.org/0000-0003-0493-5500)
- Sylvain Ranc
- Jean‐Christophe Macia (ORCID: https://orcid.org/0009-0002-7725-0529)
- Pascal Motreff (ORCID: https://orcid.org/0009-0000-3762-8916)
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Universitat Autònoma de Barcelona (ES)
- University of Padua (IT)
- Inserm (FR)
- Université de Montpellier (FR)
- Institut Pasteur de Lille (FR)
- Cardiovascular European Research Center (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Clinique du Millénaire (FR)
- Maasstad Ziekenhuis (NL)
- Les Hôpitaux de Chartres (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Hospital Clínic de Barcelona (ES)
- Hôpital Saint Joseph (FR)
- Hôpital Rangueil (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hospital Del Mar (ES)
- Institut Régional d'Administration de Bastia (FR)
- Centre Hospitalier Annecy Genevois (FR)
- Hôpital d'instruction des Armées Percy (FR)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Clinique Pasteur (FR)
- Tergooi (NL)
- Centre Hospitalier Public du Cotentin (FR)
- Centre Hospitalier Saint-Joseph Saint-Luc (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hôpital de la Timone (FR)
- Université de Nîmes (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1056/nejmoa2508808
- Citations
- 27
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 37.48
Funders
- MicroPort