First-trimester maternal serum PAPP-A levels and hyperemesis gravidarum: unraveling the link – a meta-analysis
This study provides evidence that PAPP-A levels are elevated in pregnancies complicated by hyperemesis gravidarum, implicating potential placental dysfunction and hormonal influences in its pathogenesis. While the findings are statistically significant and robust against publication bias, moderate heterogeneity highlights the need for larger prospective studies with standardized methodologies to confirm this association and explore possible underlying mechanisms. Understanding the role of PAPP-A in hyperemesis gravidarum may contribute to improved screening and management strategies for affected pregnancies and as a result, improved perinatal care.
Authors
- Panagiotis G. Antsaklis (ORCID: https://orcid.org/0000-0003-2106-5922)
- Dimitrios‐Efthymios Vlachos (ORCID: https://orcid.org/0000-0003-3740-2575)
- Vasilios Pergialiotis (ORCID: https://orcid.org/0000-0003-4510-1633)
- Nikolaos Thomakos (ORCID: https://orcid.org/0000-0003-0962-3549)
- Antonia Varthaliti (ORCID: https://orcid.org/0009-0008-8725-7103)
- Vasilios Lygizos (ORCID: https://orcid.org/0009-0001-2323-2563)
- G. Daskalakis (ORCID: https://orcid.org/0000-0001-7108-211X)
- Maria Anastasia Daskalaki (ORCID: https://orcid.org/0000-0001-6377-8379)
- Marianna Theodora (ORCID: https://orcid.org/0000-0001-8280-7796)
Institutions
- Alexandra Hospital (GR)
Publication Details
- Journal
- Journal of Perinatal Medicine
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1515/jpm-2025-0169
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00