Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder
These findings highlight a gene-disease interplay, suggesting that individuals carrying the "sensitive" allele may exhibit context-dependent alterations in salience-related brain networks. Our results identify a potential neural mechanism through which the OXTR polymorphism modulates environmental sensitivity, with distinct effects in HC and BD. Childhood trauma may shape striatocortical FC in an OXTR genotype-dependent manner.
Authors
- Po See Chen (ORCID: https://orcid.org/0000-0003-4963-578X)
- Huai‐Hsuan Tseng (ORCID: https://orcid.org/0000-0002-5213-1585)
- Shyh‐Yuh Wei (ORCID: https://orcid.org/0000-0003-3704-2434)
- Hui Hua Chang (ORCID: https://orcid.org/0000-0001-7866-5481)
Institutions
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- International Journal of Bipolar Disorders
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s40345-025-00393-8
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cheng Kung University Hospital
- National Cheng Kung University
- National Science and Technology Council