CAR T‐Cell Therapies for Patients With Relapsed and Refractory Aggressive Lymphomas: Real‐World Experiences From a Single Center on the Use of Radiotherapy
In this retrospective analysis on patients treated with CAR T-cells at our center, we report on the use of radiotherapy in this setting. Our real-world cohort of 90 patients with aggressive lymphomas was treated with CARs from 2019 until December 2022. We found that the outcome of a localized relapse after CARs treated with radiotherapy was comparable to patients without a relapse. With the knowledge from the collected real-world data, we should launch prospective clinical trials to further improve the use of radiotherapy, and overall the efficacy of CAR T-cell therapies for patients with aggressive lymphomas.
Authors
- C Ionescu (ORCID: https://orcid.org/0000-0002-9297-5061)
- Bernhard Lüscher (ORCID: https://orcid.org/0000-0003-1375-1906)
- Barbara Jeker
- Marie-Noëlle Kronig (ORCID: https://orcid.org/0009-0009-4988-4664)
- Caroline Haslebacher (ORCID: https://orcid.org/0000-0003-0674-1216)
- Michèle J. Hoffmann (ORCID: https://orcid.org/0000-0002-6044-1671)
- Jonas S. Jutzi (ORCID: https://orcid.org/0000-0002-1977-153X)
- Sabine Stamm
- Thomas Pabst (ORCID: https://orcid.org/0000-0002-6055-5257)
- Michael Daskalakis (ORCID: https://orcid.org/0000-0002-8138-0505)
- Ulrike Bacher (ORCID: https://orcid.org/0000-0001-8771-947X)
- Urban Novak (ORCID: https://orcid.org/0000-0001-7642-2101)
- Jason A. Wampfler (ORCID: https://orcid.org/0009-0007-6918-8135)
- Marc Wehrli (ORCID: https://orcid.org/0000-0001-7915-5862)
- M. Schletti
- I. Reusser
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
Publication Details
- Journal
- Hematological Oncology
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1002/hon.70124
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Inselspital, Universitätsspital Bern