PATHOGENETIC MECHANISMS OF PAIN SYNDROME IN THE LUMBOSACRAL SPINE AND MODERN APPROACHES TO CONSERVATIVE THERAPY

Pain in the lumbosacral spine is one of the most common complaints in clinical practice and a leading cause of disability in developed countries.According to epidemiological studies, lifetime prevalence ranges from 60% to 90%, and by 2050, the number of patients is projected to increase to 843 million people.The article analyzes the anatomical and physiological features of the lumbosacral spine and pathogenetic mechanisms of pain syndrome development, including peripheral nociception, central sensitization, neuroplastic changes, and the role of inflammatory processes.Modern methods of conservative therapy based on the biopsychosocial model and multimodal approach are considered.Through systematic analysis of scientific literature, it was established that the pathogenesis of pain Vda a perspektivy 8(51) 2025