Fluoride intake during pregnancy: calculation of realistic exposure scenarios for individual risk assessment

Using the methodological approach of systematic review several regulatory bodies and associations have performed an assessment of existing evidence on the adverse effects of fluoride. The most recent review by EFSA published in 2025 recommended a fluoride level in drinking water of below 1.5 mg/L and a maximum total daily intake of 3.3 mg of fluoride as safe level with particular respect to pregnant women and the exposed unborn child. Our work focusses on individual exposure aspects, evaluating the contribution of major sources, specifically those which can be influenced by personal behaviour. We demonstrate that black or green tea and fluoridated household salt-even at salt intake levels below the population 25th percentile-are main contributors of the daily fluoride exposure in the population. Using the safe level proposed by EFSA, we have calculated different exposure scenarios that may be used by individuals to estimate their specific exposure to fluoride from known sources. Considering that the safe level proposed by EFSA can be exceeded e.g. by drinking more than two cups (300 mL) of black or green tea daily and using even low amounts of fluoridated salt, our findings highlight the need for clear labelling of the fluoride content of products to allow informed consumer choices.

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Publication Details

Journal
Archives of Toxicology
Published
2025-08-31
DOI
https://doi.org/10.1007/s00204-025-04143-8
Citations
1
Primary Topic
Fluoride Effects and Removal
Type
article
Field-Weighted Citation Impact
0.82
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article

Fluoride intake during pregnancy: calculation of realistic exposure scenarios for individual risk assessment

Heidi Foth, Thomas Schupp, Monika Batke, Aswin Mangerich et al.
1 citations
Archives of Toxicology
Fluoride Effects and Removal
0.82
article

Fluoride intake during pregnancy: calculation of realistic exposure scenarios for individual risk assessment

Heidi Foth, Thomas Schupp, Monika Batke, Aswin Mangerich, Alexius Freyberger, Ursula Gundert‐Remy, Jan Georg Hengstler, Falko Partosch, Georg Damm, J. vom Brocke, Anna Sonnenburg, Klaus‐Michael Wollin
article en
1 citations

Abstract

Using the methodological approach of systematic review several regulatory bodies and associations have performed an assessment of existing evidence on the adverse effects of fluoride. The most recent review by EFSA published in 2025 recommended a fluoride level in drinking water of below 1.5 mg/L and a maximum total daily intake of 3.3 mg of fluoride as safe level with particular respect to pregnant women and the exposed unborn child. Our work focusses on individual exposure aspects, evaluating the contribution of major sources, specifically those which can be influenced by personal behaviour. We demonstrate that black or green tea and fluoridated household salt-even at salt intake levels below the population 25th percentile-are main contributors of the daily fluoride exposure in the population. Using the safe level proposed by EFSA, we have calculated different exposure scenarios that may be used by individuals to estimate their specific exposure to fluoride from known sources. Considering that the safe level proposed by EFSA can be exceeded e.g. by drinking more than two cups (300 mL) of black or green tea daily and using even low amounts of fluoridated salt, our findings highlight the need for clear labelling of the fluoride content of products to allow informed consumer choices.

Archives of ToxicologyVol. 99(12)
University of Potsdam (DE), TU Dortmund University (DE), Federal Institute for Risk Assessment (DE), Finnish Safety and Chemicals Agency (FI), Ramboll (Germany) (DE), University of Applied Sciences Emden Leer (DE), University Hospital Leipzig (DE), Leibniz Research Centre for Working Environment and Human Factors (DE), European Chemicals Agency, FH Münster University of Applied Sciences (DE), Bayer (Germany) (DE), Charité - Universitätsmedizin Berlin (DE), Leipzig University (DE)
Openalex Percentile: Top 23%
Fluoride Effects and Removal
0.82
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