Genetically proxied tumour necrosis factor inhibition and pregnancy-related maternal and foetal outcomes in the general population: a Mendelian randomization study
This genetic investigation found no evidence linking TNFi to adverse pregnancy-related outcomes. The suggestive association with a reduced risk of gestational diabetes warrants further research and may support its consideration for at-risk pregnant women.
Authors
- Benjamin Woolf (ORCID: https://orcid.org/0000-0002-1505-2570)
- Sizheng Steven Zhao (ORCID: https://orcid.org/0000-0002-3558-7353)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Tormod Rogne (ORCID: https://orcid.org/0000-0002-9581-7384)
Institutions
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Yale University (US)
- University of Bristol (GB)
- Perinatal Institute (GB)
- Providence Center (US)
- MRC Biostatistics Unit (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Rheumatology Advances in Practice
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/rap/rkaf100
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00