Spotlight on innovation: key insights from the extracellular vesicle cluster meeting at the European Innovation Council
The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration with the Horizon2020-funded BOW project, organized the "Extracellular Vesicle EIC Cluster Meeting," bringing together researchers, startups, and regulatory stakeholders across Europe. Discussions focused on overcoming bottlenecks in EV production, standardization, and clinical readiness. Key outcomes included the need for application-specific benchmarks, robust manufacturing pipelines, and regulatory frameworks tailored to EVs. The event emphasized the importance of interdisciplinary collaboration, coopetition, and continued EU funding to drive innovation and strengthen Europe's leadership in the EV field.
Authors
- Paolo Bergese (ORCID: https://orcid.org/0000-0002-4652-2168)
- Eva Rohde (ORCID: https://orcid.org/0000-0001-8692-886X)
- Christian Néri (ORCID: https://orcid.org/0000-0002-3790-2978)
- Bernd Giebel (ORCID: https://orcid.org/0000-0003-2446-948X)
- George A. Garinis (ORCID: https://orcid.org/0000-0002-3200-5004)
- Petra Ohlsson
- Marcella Chiari (ORCID: https://orcid.org/0000-0002-4670-1430)
- Marı́a Yáñez-Mó (ORCID: https://orcid.org/0000-0001-7484-2866)
- Nataša Zarovni (ORCID: https://orcid.org/0000-0003-2983-7886)
- Seppo Vainio (ORCID: https://orcid.org/0000-0001-9319-3566)
- Valentina Cauda (ORCID: https://orcid.org/0000-0003-2382-1533)
- Marca H. M. Wauben (ORCID: https://orcid.org/0000-0003-0360-0311)
- Giorgia Adamo (ORCID: https://orcid.org/0000-0002-6887-763X)
- Paolo Guazzi
- M. Goreti F. Sales (ORCID: https://orcid.org/0000-0001-9936-7336)
- Benedetta Bussolati (ORCID: https://orcid.org/0000-0002-3663-5134)
- Marcin Jurga (ORCID: https://orcid.org/0000-0002-2789-1048)
- Pieter Vader
- Iordanis Arzimanoglou
- Irene Trapani
- Ioannis Amarantos
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Liège (BE)
- University of Applied Sciences Utrecht (NL)
- Politecnico di Torino (IT)
- Utrecht University (NL)
- Paracelsus Medical University (AT)
- Ideon Science Park (SE)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (IT)
- Institut de Biologie Paris-Seine (FR)
- Construction Technologies Institute (IT)
- Institute for Biomedical Research and Innovation (IT)
- Salzburger Landeskliniken (AT)
- Centro de Biología Molecular Severo Ochoa (ES)
- HansaBioMed (Estonia) (EE)
- National Research Council (IT)
- ASIT Biotech (Belgium) (BE)
- Daye People's Hospital (CN)
- University of Turin (IT)
- University of Duisburg-Essen (DE)
- Universidad Autónoma de Madrid (ES)
- University of Coimbra (PT)
- University of Brescia (IT)
- Foundation for Research and Technology Hellas (GR)
- University of Oulu (FI)
Publication Details
- Journal
- Cytotherapy
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1016/j.jcyt.2025.08.008
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme