Overall survival of recurrent/metastatic head & neck squamous cell carcinoma patients progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy: results of SAKK 11/16,
These findings suggest that MVX-ONCO-1 can induce a coordinated immune response with clinical benefits as a standalone treatment, leading to prolonged survival. This effect may be enhanced by previous exposure to immune checkpoint inhibitors. Trial registration (ClinicalTrials.gov): NCT02999646.
Authors
- Olivier Michielin (ORCID: https://orcid.org/0000-0003-4926-6355)
- Marie‐Claude Belkouch
- Nicolas Mach (ORCID: https://orcid.org/0000-0001-8944-1088)
- Markus Joerger (ORCID: https://orcid.org/0000-0001-6602-6287)
- Emily Charrier (ORCID: https://orcid.org/0000-0001-6143-509X)
- Tamara Rordorf
- Valentin Saingier
- Eugenio Fernández (ORCID: https://orcid.org/0000-0002-3813-1888)
- Muriel Urwyler
- Fabien Courtout
- Julien Grogg (ORCID: https://orcid.org/0000-0002-9479-0933)
- Virginie Ancrenaz
- Jessica Renaux
- Wolfram Karenovicŝ (ORCID: https://orcid.org/0000-0003-4523-4073)
- Rémi Vernet (ORCID: https://orcid.org/0000-0003-0213-3539)
- Olivier Von Rohr
- Nicolas Dulguerov (ORCID: https://orcid.org/0000-0001-8676-3698)
- Jean Villard (ORCID: https://orcid.org/0000-0003-2667-7506)
- Tomas Brezina
- Gisela Müller (ORCID: https://orcid.org/0009-0002-2993-8062)
- Claudio DeVito
- Katrin Gobat
Institutions
- University of Geneva (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- Swiss Group For Clinical Cancer Research (CH)
- Swiss Cancer Center Léman (CH)
- University Hospitals Geneva Medical Center (US)
- Geneva College (US)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s40164-025-00703-x
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Gateway for Cancer Research
- Krebsliga Schweiz
- Université de Genève
- Innosuisse - Schweizerische Agentur für Innovationsförderung
- Rising Tide Foundation