In Silico Evaluation of Vitamin D3 as a Dual Inhibitor of CDK2 and Bcl-2 in Colorectal Cancer
This study provides the first computational evidence that vitamin D3 may exert anticancer effects in CRC via dual mechanisms-cell cycle arrest through CDK2 inhibition and apoptosis induction through Bcl-2 modulation. These findings offer a novel perspective on the therapeutic repositioning of vitamin D3 as a multi-target agent in CRC management and warrant further validation through in vitro and in vivo studies.
Authors
- Mostafa Aly (ORCID: https://orcid.org/0000-0001-6154-2258)
- Sri Puji Astuti Wahyuningsih (ORCID: https://orcid.org/0000-0003-1027-7110)
- Dwi Winarni (ORCID: https://orcid.org/0000-0001-7688-0620)
- Mochammad Aqilah Herdiansyah (ORCID: https://orcid.org/0009-0006-9383-6203)
- Jauharotus Shobahah
Institutions
- Universitas Airlangga (ID)
Publication Details
- Journal
- Open Veterinary Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5455/ovj.2025.v15.i8.40
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lembaga Pengelola Dana Pendidikan