Experimental induction of Theileria annulata infection in rabbits: immunopathological, biochemical, and histopathological analysis

The infection altered the red blood cell structure of the host, as well as increased body temperature and mortality. Increased levels of proinflammatory markers (e.g., IFN-γ), decreased levels of antiinflammatory cytokines (IL-10 and TGF-β1), higher oxidative stress (e.g., MDA, reduced TAC), and persistent IgG responses indicate systemic immunological activation. Histopathological changes revealed increased lung, liver, spleen, kidney, and lymph node damage.