Plasma proteomics in septic shock and alcohol-related pancreatitis: a hyaluronan-centered approach
The present study explored the role of hyaluronan-related proteins in septic shock pathophysiology, revealing potential dysregulation associated with sepsis severity. The decrease in ITIH1, ITIH2 and ITIH4, as compared to the increase in ITIH3, suggest a complex alteration in the protein balance of the IαI-family in sepsis. Overall, the altered proteomic profile of hyaluronan-related proteins as reflected by the GO terms indicates a complex dysregulation not only in hyaluronan metabolism and extracellular matrix, but also in the regulation of several proteolytic enzymes. Future studies on this area are warranted.
Authors
- Jyrki Tenhunen
- Egor Vorontsov (ORCID: https://orcid.org/0000-0002-0029-987X)
- Marko Sallisalmi (ORCID: https://orcid.org/0000-0001-9880-4557)
- Jaap van der Heijden (ORCID: https://orcid.org/0000-0002-4205-7131)
- Annelie Barrueta Tenhunen (ORCID: https://orcid.org/0000-0003-0815-375X)
- Asanda Mazubane
Institutions
- Uppsala University (SE)
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s12014-025-09556-2
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Akademiska Sjukhuset
- Uppsala Universitet