Pemafibrate treatment produces antidepressant-like effects in CUMS and CRS models through activation of hippocampal PPARα and BDNF signaling
Pemafibrate exerts antidepressant-like effects in both CUMS and CRS mouse models by promoting hippocampal PPARα and BDNF signaling.
Authors
- Bo Jiang (ORCID: https://orcid.org/0000-0002-1577-7272)
- Huahao Fan (ORCID: https://orcid.org/0000-0001-5007-2158)
- Wei Liu
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0002-0507-6317)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-8440-2274)
- Zhiming Cui (ORCID: https://orcid.org/0000-0001-9197-5548)
- Hui Xu (ORCID: https://orcid.org/0000-0001-6856-9314)
- Jin Zhou (ORCID: https://orcid.org/0000-0002-2291-9283)
- Si-Yi Zhou
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1093/ijnp/pyaf063
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province