Extraction and Screening of Gastroprotective Activity of Morus Alba Linn.

The purpose of the present study was to evaluate the anti-ulcer effect of Morus alba Linn. The alcoholic extract of Morus alba Linn. leaves were evaluated for its anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats, water immersion stress induced ulcer models in rats and HCl-ethanol induced ulcer in mice at two different doses viz. 100 and 200 mg/kg. Biochemical parameters like volume of gastric secretion, pH, free acidity, total acidity and ulcer index were studied. The alcoholic extract of Morus alba Linn. leaves showed significant reduction in gastric volume, pH, free acidity, total acidity and ulcer index at concentration of 100 & 200 mg/kg. The plant extract at concentration of 200mg/kg showed significant gastro protective activity 82.36%, compared with standard drug sucralfate showed 91.18% and protection index in water immersion stress induced ulcer showed 92.14% compared with standard drug omeprazole showed protection index 99.58%. The results suggest that the alcoholic extract of Morus alba Linn. leaves possesses anti-ulcer effect. The observed effect may be due to the presence of bioactive constituents. KEYWORDS: Anti-ulcer, Morus alba, Methanol, Saponin.