Uptake and 24-month Outcomes of Dolutegravir- Versus Lopinavir-based Second-line Antiretroviral Therapy for People With HIV in South Africa: A Retrospective Cohort Study and Emulated Target Trial
While retention was similar across regimens, viremia was less common on DTG-based ART, supporting current guidelines.
Authors
- Yukteshwar Sookrajh (ORCID: https://orcid.org/0000-0001-9029-5153)
- Nigel Garrett (ORCID: https://orcid.org/0000-0002-4530-234X)
- Lara Lewis (ORCID: https://orcid.org/0000-0001-5373-2086)
- Mlungisi Khanyile
- Jennifer Anne Brown (ORCID: https://orcid.org/0000-0003-1874-6153)
- Christian Bottomley (ORCID: https://orcid.org/0000-0002-5241-8412)
- Kwabena Asare (ORCID: https://orcid.org/0000-0002-5074-2315)
- Jienchi Dorward (ORCID: https://orcid.org/0000-0001-6072-1430)
- Thokozani Khubone (ORCID: https://orcid.org/0000-0002-2488-6454)
- Johan van der Molen (ORCID: https://orcid.org/0009-0009-7290-7107)
- Kwena Tlhaku (ORCID: https://orcid.org/0000-0002-2105-9146)
- Thulani Ngwenya
- Lungile Hobe
Institutions
- Desmond Tutu HIV Foundation (ZA)
- University of Cape Town (ZA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- eThekwini Municipality (ZA)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Addington Hospital (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1093/ofid/ofaf530
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00