Exposure to Bovine Viral Diarrhea Virus Disrupts Intestinal Barrier Function via NLRP3/Caspase-1-Mediated Pyroptosis and Gut Microbiota Dysbiosis

Bovine viral diarrhea virus (BVDV) is a major global pathogen that causes severe economic losses in dairy herds due to diarrhea, reproductive disorders, and reduced milk yield. Despite its well-documented systemic effects, the mechanism of BVDV-induced intestinal damage remains unclear. In our study, BVDV triggered cytopathic effects in intestinal epithelial cells, including cell death, goblet cell depletion, and disruption of barrier proteins. Although BVDV alters gut microbiota by activating the NLRP3/caspase-1 inflammasome pathway and thereby causing pyroptosis and intestinal injury, fecal microbiota transplantation mitigated those effects by suppressing NLRP3/caspase-1's activation. Those findings reveal key pathways in BVDV's pathogenesis and suggest novel therapeutic strategies to combat livestock infections.

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Publication Details

Journal
Journal of Agricultural and Food Chemistry
Published
2025-08-30
DOI
https://doi.org/10.1021/acs.jafc.5c04854
Citations
1
Primary Topic
Viral gastroenteritis research and epidemiology
Type
article
Field-Weighted Citation Impact
1.40

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article

Exposure to Bovine Viral Diarrhea Virus Disrupts Intestinal Barrier Function via NLRP3/Caspase-1-Mediated Pyroptosis and Gut Microbiota Dysbiosis

Fei‐Fei Liu, Ke Ding, Ying Wei, Chengshui Liao et al.
1 citations
Journal of Agricultural and Food Chemistry
Viral gastroenteritis research and epidemiology
1.40
article

Exposure to Bovine Viral Diarrhea Virus Disrupts Intestinal Barrier Function via NLRP3/Caspase-1-Mediated Pyroptosis and Gut Microbiota Dysbiosis

Fei‐Fei Liu, Ke Ding, Ying Wei, Chengshui Liao, Dingjiacheng Jia, Zuhua Yu, Jian Chen, Xinyu Han, Lei He, Songbiao Chen
article en
1 citations

Abstract

Bovine viral diarrhea virus (BVDV) is a major global pathogen that causes severe economic losses in dairy herds due to diarrhea, reproductive disorders, and reduced milk yield. Despite its well-documented systemic effects, the mechanism of BVDV-induced intestinal damage remains unclear. In our study, BVDV triggered cytopathic effects in intestinal epithelial cells, including cell death, goblet cell depletion, and disruption of barrier proteins. Although BVDV alters gut microbiota by activating the NLRP3/caspase-1 inflammasome pathway and thereby causing pyroptosis and intestinal injury, fecal microbiota transplantation mitigated those effects by suppressing NLRP3/caspase-1's activation. Those findings reveal key pathways in BVDV's pathogenesis and suggest novel therapeutic strategies to combat livestock infections.

Journal of Agricultural and Food ChemistryVol. 73(36)
Ministry of Education of the People's Republic of China (CN), Henan University of Science and Technology (CN), Kerala Veterinary and Animal Sciences University (IN), China Animal Disease Control Center (CN), Département Santé Animale (FR), Taiwan Centers for Disease Control (TW), Henan Institute of Science and Technology (CN)
Natural Science Foundation of Henan Province, Henan Provincial Science and Technology Research Project
Zero hunger
Openalex Percentile: Top 17%
Viral gastroenteritis research and epidemiology
1.40
DOISourceOpenAlex
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