Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk
In this IPD meta-analysis of 4 RCTs, and an overall meta-analysis of 8 RCTs of patients with severe symptomatic AS at low to intermediate risk, TAVI was associated with a reduction in the 1-year incidence of all-cause death or any stroke. These findings emphasize TAVI as alternative option in patients at low to intermediate risk. Long-term follow-up is warranted to evaluate sustainability of these findings.
Authors
- William D. Toff (ORCID: https://orcid.org/0000-0001-5631-4496)
- Juan F. Granada (ORCID: https://orcid.org/0000-0003-2399-8320)
- Troels Højsgaard Jørgensen (ORCID: https://orcid.org/0000-0002-8422-7127)
- Jemma Hudson (ORCID: https://orcid.org/0000-0002-6440-6419)
- Matthias Klimek (ORCID: https://orcid.org/0000-0002-6331-0992)
- Christina Magnussen (ORCID: https://orcid.org/0000-0002-5102-0955)
- Stefan Blankenberg (ORCID: https://orcid.org/0000-0001-6488-2362)
- Olaf Wendler (ORCID: https://orcid.org/0000-0002-7494-5774)
- Andreas Ziegler (ORCID: https://orcid.org/0000-0002-8386-5397)
- Hans Gustav Hørsted Thyregod (ORCID: https://orcid.org/0000-0002-9385-8318)
- Sebastian Ludwig (ORCID: https://orcid.org/0000-0002-5752-4951)
- David Hildick‐Smith (ORCID: https://orcid.org/0000-0002-1147-1436)
- Moritz Seiffert (ORCID: https://orcid.org/0000-0002-3940-9079)
- Holger Thiele
- Benjamin Bay
- Ole De Backer
- Martin B. Leon
Institutions
- NewYork–Presbyterian Hospital (US)
- University of Leicester (GB)
- Universität Hamburg (DE)
- University of Aberdeen (GB)
- New York Hospital Queens (US)
- Glenfield Hospital (GB)
- Rigshospitalet (DK)
- National Institute for Health and Care Research (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Leipzig Heart Institute (DE)
- German Centre for Cardiovascular Research (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Cardiovascular Research Foundation (US)
- Cleveland Clinic London (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- NIHR Biomedical Research Centre at The Royal Marsden and the ICR
- Columbia University (US)
- Ruhr University Bochum (DE)
- Leipzig University (DE)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- JAMA Cardiology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1001/jamacardio.2025.3403
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39