Fibroblast growth factor 2 promotes matrix vesicle-mediated mineralization of human umbilical cord perivascular cells by regulating phosphate metabolism
FGF2 enhances HUCPVC-mediated mineralization via dual regulation: ALP induction and ENPP1-PPi suppression. These findings support the therapeutic potential of FGF2 in bone tissue engineering and implant surface integration.
Authors
- Risako Chiba-Ohkuma
- Shun Nonoyama
- Yasuo Yamakoshi (ORCID: https://orcid.org/0000-0003-2134-5860)
- Ryûji Yamamoto (ORCID: https://orcid.org/0009-0002-9215-544X)
- Kazuhiro Gomi (ORCID: https://orcid.org/0000-0003-4484-6238)
- Takeo Karakida
- Takatoshi Nagano (ORCID: https://orcid.org/0000-0001-7708-2292)
- Sakurako Asada
Institutions
- Tsurumi University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1016/j.job.2025.100693
- Primary Topic
- Dermatological and Skeletal Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science