Long-Term Prednisone Use Increases Hepatocellular Carcinoma Risk in Autoimmune Hepatitis Cirrhosis: A Retrospective Cohort Study
The study findings suggested that prolonged prednisone exposure in patients with AIH-cirrhosis independently contributes to HCC development. This association appears to be supported by mechanistic pathways, driven by prednisone's dose-dependent immunosuppressive and metabolic effects, disrupting immune surveillance, promoting hepatic fibrosis, and oncogenic pathways.
Authors
- Walid S. Ayoub (ORCID: https://orcid.org/0000-0002-9123-5918)
- Manaf Alsudaney (ORCID: https://orcid.org/0000-0003-0760-0925)
- Abdelrahman M. Attia (ORCID: https://orcid.org/0000-0002-5941-9717)
- Soo Young Hwang (ORCID: https://orcid.org/0000-0001-9845-7073)
- Naomy Kim (ORCID: https://orcid.org/0009-0008-7747-514X)
- Jessica Liu (ORCID: https://orcid.org/0000-0002-7427-8959)
- Pojsakorn Danpanichkul (ORCID: https://orcid.org/0000-0002-9121-165X)
- Hasmik Adetyan
- Tamar Yalda
- Rami Hemadeh
Institutions
- Texas Tech University (US)
- Cedars-Sinai Medical Center (US)
- Rosalind Franklin University of Medicine and Science (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100784
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00