Hypoxia-induced radioresistance in squamous cell carcinoma of the anus treated with radiotherapy − a validating study
The expression of the 15 hypoxia-related genes and classification of tumors as more or less hypoxic based on pre-treatment tumor tissue were prognostic for LRF in a large SCCA dataset. This underlines the importance of hypoxia in SCCA and validates the results from the previous hypothesis-generating study.
Authors
- Karen Lycke Wind (ORCID: https://orcid.org/0000-0003-2961-7277)
- Kasper Toustrup
- Katrine Stribolt
- Karen‐Lise Garm Spindler (ORCID: https://orcid.org/0000-0001-8781-3212)
- Brita Singers Sørensen (ORCID: https://orcid.org/0000-0002-3955-4735)
- Alexis Lefèvre (ORCID: https://orcid.org/0000-0003-2262-3092)
- Jens Overgaard (ORCID: https://orcid.org/0000-0002-0814-8179)
- Jan Alsner (ORCID: https://orcid.org/0000-0002-5395-3193)
- Søren Krag (ORCID: https://orcid.org/0000-0003-1975-2766)
Institutions
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1016/j.radonc.2025.111118
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kræftens Bekæmpelse