A systemic and dialectical paradigm for Psychoneuroendocrineimmunology and integrated care science

The integrated care needs of a philosophical paradigm. Psychoneuroendocrineimmunology can be it, provided that a consensus is created on its profound meaning. What is Psychoneuroendocrineimmunology (PNEI)? It is not Neuroendocrinoimmunology. PNEI (also called PNI, Psychoneuroimmunology) describes the relationships of mutual influence between the psyche and biological systems and between the whole organism and the physical and social environment, showing the scientific inconsistency of the reductionist dogma that makes the psyche a mere epiphenomenon of brain activity. We are in a phase of research that allows the definitive overcoming of the dualistic conception of the human being without falling into the trap of the mind-brain identity, in the reduction of the psychic dimension to the biological one, from which it undoubtedly originates but on which it influences. To this end, it is essential to critique the philosophical foundations of contemporary reductionism, while, at the same time, highlighting the theoretical-conceptual paradigm that underlies PNEI research and the practice of treatments that integrate medicine and psychology, which descend from this paradigm.

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Publication Details

Journal
Brain Behavior and Immunity Integrative
Published
2025-08-30
DOI
https://doi.org/10.1016/j.bbii.2025.100138
Primary Topic
Stress Responses and Cortisol
Type
article
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article

A systemic and dialectical paradigm for Psychoneuroendocrineimmunology and integrated care science

Francesco Bottaccioli, Anna Giulia Bottaccioli
Brain Behavior and Immunity Integrative
Stress Responses and Cortisol
article

A systemic and dialectical paradigm for Psychoneuroendocrineimmunology and integrated care science

Francesco Bottaccioli, Anna Giulia Bottaccioli
article en

Abstract

The integrated care needs of a philosophical paradigm. Psychoneuroendocrineimmunology can be it, provided that a consensus is created on its profound meaning. What is Psychoneuroendocrineimmunology (PNEI)? It is not Neuroendocrinoimmunology. PNEI (also called PNI, Psychoneuroimmunology) describes the relationships of mutual influence between the psyche and biological systems and between the whole organism and the physical and social environment, showing the scientific inconsistency of the reductionist dogma that makes the psyche a mere epiphenomenon of brain activity. We are in a phase of research that allows the definitive overcoming of the dualistic conception of the human being without falling into the trap of the mind-brain identity, in the reduction of the psychic dimension to the biological one, from which it undoubtedly originates but on which it influences. To this end, it is essential to critique the philosophical foundations of contemporary reductionism, while, at the same time, highlighting the theoretical-conceptual paradigm that underlies PNEI research and the practice of treatments that integrate medicine and psychology, which descend from this paradigm.

Brain Behavior and Immunity IntegrativeVol. 12
Humanitas University (IT), University of Milan (IT), Società Italiana di Nefrologia (IT), Istituto Psicoanalitico per le Ricerche Sociali (IT), Mylan (Switzerland) (CH)
Openalex Percentile: Top 76%
Stress Responses and Cortisol
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A systemic and dialectical paradigm for Psychoneuroendocrineimmunology and integrated care science — Francesco Bottaccioli, Anna Giulia Bottaccioli · Brain Behavior and Immunity Integrative (2025) | TGRS Research Map | TGRS