Determinants of oncologic outcomes in high‐grade organ‐confined prostate cancer after prostatectomy
Four hundred and seven RPs were initially assessed: 236 (58%) with GG 4 and 171 (42%) with GG 5 prostate cancer (PCa). Survival analysis was performed on subsets of patients with available follow-up (BCR: n = 343, metastases: n = 347) to identify clinicopathologic variables associated with the risk of biochemical recurrence and metastasis. The size of the dominant nodule (cut-off 15 mm) (HR 1.654, 95% CI 1.026-2.667; P = 0.04) and the preoperative PSA level (HR 1.052, 95% CI 1.009-1.097; P = 0.02) were associated with a higher likelihood of BCR on univariate regression analysis, with only preoperative PSA remaining significant when both variables were assessed concurrently (HR 1.051, 95% CI 1.007-1.098; P = 0.02). On univariate Cox regression analysis, the size of the dominant nodule (cut-off: 15 mm; HR 6.315, 95% CI 2.021-19.725; P < 0.01), the presence of large cribriform components (HR 4.375, 95% CI 0.999-19.159; P = 0.05), and LVI (HR 3.808, 95% CI 1.086-13.354; P = 0.04) were associated with the risk of metastasis, but only size remained an independent predictor on multivariate analysis (HR 5.66, 95% CI 1.761-18.191; P < 0.01In p for cut-off of 15 mm).
Authors
- Kenneth A. Iczkowski (ORCID: https://orcid.org/0000-0002-8909-8811)
- Omer Abdelaziz Mohammed Saeed (ORCID: https://orcid.org/0000-0002-4584-9222)
- Mohammad Salimian
- Leland W.K. Chung (ORCID: https://orcid.org/0000-0003-0072-6939)
- Lisa Marcolini (ORCID: https://orcid.org/0000-0003-0044-8991)
- Nicholas Baniak
- Andres Martin Acosta (ORCID: https://orcid.org/0000-0001-8817-6331)
- Anna Caliò (ORCID: https://orcid.org/0000-0001-7352-6327)
- Toyonori Tsuzuki (ORCID: https://orcid.org/0000-0002-4855-4366)
- Shivani Kandukuri
- Douglas Wu
- Květoslava Michalová (ORCID: https://orcid.org/0000-0003-3231-6870)
- Adeboye O. Osunkoya (ORCID: https://orcid.org/0000-0001-5712-8134)
- Guido Martignoni (ORCID: https://orcid.org/0000-0002-7761-7274)
- Angela Pecoraro
- Alicia Cuber
- Éva Compérat (ORCID: https://orcid.org/0000-0001-8488-543X)
- Hiroshi Miyamoto (ORCID: https://orcid.org/0000-0001-7610-7769)
- Ezra Baraban (ORCID: https://orcid.org/0000-0001-6932-8985)
- Geert J.L.H. van Leenders (ORCID: https://orcid.org/0000-0003-2176-9102)
- Andrea Straková-Peteříková
- Ying Wang (ORCID: https://orcid.org/0000-0003-2121-7025)
- Reem Youssef
- Ankur R Sangoi (ORCID: https://orcid.org/0009-0007-7233-2361)
Institutions
- University of Verona (IT)
- Johns Hopkins University (US)
- Emory University (US)
- Charles University (CZ)
- Keck Hospital of USC (US)
- Johns Hopkins Bayview Medical Center (US)
- University of Rochester Medical Center (US)
- University of Saskatchewan (CA)
- Aichi Medical University Hospital (JP)
- Biopticka Laborator (Czechia) (CZ)
- Erasmus MC Cancer Institute (NL)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Medical University of Vienna (AT)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1111/his.15547
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00