Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib
Although retrospective, these data support the hypothesis that NRG1 VUSes are frequently associated with poor prognosis and other oncogene alterations. In EGFR M+ patients treated with osimertinib, concurrent NRG1 alterations were an independent poor prognostic factor for both PFS and OS, raising the need of further validation.
Authors
- John Erol Evangelista (ORCID: https://orcid.org/0000-0003-4836-0518)
- Antonio Vitale (ORCID: https://orcid.org/0000-0003-1582-8006)
- Rocco Trisolini (ORCID: https://orcid.org/0000-0002-1067-4696)
- Federico Monaca (ORCID: https://orcid.org/0000-0002-3265-6755)
- Giovanni Scambia (ORCID: https://orcid.org/0000-0002-9503-9041)
- Emilio Bria (ORCID: https://orcid.org/0000-0002-2333-704X)
- Emanuele Vita (ORCID: https://orcid.org/0000-0003-4546-547X)
- Elisa De Paolis (ORCID: https://orcid.org/0000-0002-0780-0153)
- Luca Mastrantoni (ORCID: https://orcid.org/0000-0003-1853-4927)
- Giampaolo Tortora (ORCID: https://orcid.org/0000-0002-1378-4962)
- Alessandra Cancellieri (ORCID: https://orcid.org/0000-0002-5895-4419)
- Mariantonietta Di Salvatore
- A. Stefani
- Camilla Nero (ORCID: https://orcid.org/0000-0002-4442-4046)
- Alessandro Scala
- Angelo Minucci (ORCID: https://orcid.org/0000-0002-0833-4334)
- A. Cosmai
- S. Polidori
- J. Russo
- Fiorella D’Auria (ORCID: https://orcid.org/0000-0002-3030-1651)
- P. Troisi
- G. Horn
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105556
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00