Long-Term Safety and Effectiveness of Sebetralstat: Interim Analysis of KONFIDENT-S Open-label Extension
Oral sebetralstat enabled compliance with treatment guidelines. No new safety signals were observed, and effectiveness for repeated attacks was consistent with the KONFIDENT trial results.
Authors
- Teresa Caballero (ORCID: https://orcid.org/0000-0003-3005-9858)
- Sinisa Savic (ORCID: https://orcid.org/0000-0001-7910-0554)
- Daniel Soteres (ORCID: https://orcid.org/0000-0002-7433-0171)
- Jonny Peter (ORCID: https://orcid.org/0000-0002-2658-0723)
- Paul K. Audhya
- James Hao
- Vesna Grivcheva‐Panovska (ORCID: https://orcid.org/0000-0002-0961-7002)
- Matthew Iverson
- Mar Guilarte (ORCID: https://orcid.org/0000-0001-7242-9584)
- Maria Staevska (ORCID: https://orcid.org/0000-0002-9154-303X)
- Petra Staubach (ORCID: https://orcid.org/0000-0002-2276-0284)
- Raffi Tachdjian (ORCID: https://orcid.org/0000-0002-5387-0013)
- Laurence Bouillet (ORCID: https://orcid.org/0000-0001-8245-4767)
- Sorena Kiani‐Alikhan (ORCID: https://orcid.org/0000-0002-1299-4415)
- Marc A. Riedl (ORCID: https://orcid.org/0000-0003-3460-1544)
- Mauro Cancian (ORCID: https://orcid.org/0000-0003-2246-9144)
- John Anderson (ORCID: https://orcid.org/0000-0003-3578-8064)
- Henry Kanarek
- Tamar Kinaciyan (ORCID: https://orcid.org/0000-0002-8238-2561)
- Michael D. Smith (ORCID: https://orcid.org/0000-0001-6844-7923)
- Danny M. Cohn (ORCID: https://orcid.org/0000-0002-9036-3723)
- Anna Valerieva (ORCID: https://orcid.org/0000-0002-0417-9840)
- Marcin Stobiecki (ORCID: https://orcid.org/0000-0003-0161-4920)
- Andrea Zanichelli (ORCID: https://orcid.org/0000-0002-7512-4644)
- Daisuke Honda (ORCID: https://orcid.org/0000-0001-5624-7553)
- Christopher Yea
- Jonathan A. Bernstein (ORCID: https://orcid.org/0000-0002-3476-1196)
- Patrick Yong (ORCID: https://orcid.org/0000-0003-1736-2756)
- Emel Aygören‐Pürsün
- Hilary Longhurst (ORCID: https://orcid.org/0000-0003-2891-566X)
- William R. Lumry (ORCID: https://orcid.org/0000-0001-7608-5416)
- Marcus Maurer (ORCID: https://orcid.org/0000-0002-4121-481X)
- Michael Manning (ORCID: https://orcid.org/0000-0003-4455-7356)
- Isaac Melamed (ORCID: https://orcid.org/0000-0003-0094-9091)
- Inmaculada Martinez‐Saguer
- Timothy Craig
- Atsushi Fukunaga
- Markus Magerl
- Maeve O’Connor
- Damia Leguevaques
Institutions
- Luminex (United States) (US)
- Semmelweis University (HU)
- Goethe University Frankfurt (DE)
- Jagiellonian University (PL)
- Centre National de la Recherche Scientifique (FR)
- Alabama Department of Public Health (US)
- La Jolla Institute for Immunology (US)
- University of Padua (IT)
- University of Auckland (NZ)
- Johannes Gutenberg University Mainz (DE)
- Alexandrovska Hospital (BG)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Hospital Universitario La Paz (ES)
- UC San Diego Health System (US)
- Auckland City Hospital (NZ)
- Groote Schuur Hospital (ZA)
- Frimley Health NHS Foundation Trust (GB)
- Medical University of Sofia (BG)
- Centre Hospitalier Universitaire de Lille (FR)
- University of California San Diego (US)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- IRCCS Policlinico San Donato (IT)
- Chiba University Hospital (JP)
- Haemophilia Foundation Australia (AU)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital La Paz Institute for Health Research (ES)
- Saint John's Health Center (US)
- Vinmec Times City International Hospital (VN)
- IMMUNOe Research Center (US)
- Bernstein Clinical Research Center (US)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- KalVista Pharmaceuticals (United States) (US)
- Vall d'Hebron Hospital Universitari (ES)
- University Hospital Frankfurt (DE)
- HolsboerMaschmeyer NeuroChemie (Germany) (DE)
- Allergy Associates Research Center (US)
- Amsterdam University Medical Centers (NL)
- Asthma and Allergy Specialists (US)
- Institute of Infection and Immunity (CA)
- Adult and Pediatric Dermatology (US)
- University College London (GB)
- Phoenix College (US)
- University of Cincinnati (US)
- Medical University of Vienna (AT)
- Ss. Cyril and Methodius University in Skopje (MK)
- University of Amsterdam (NL)
- Université Grenoble Alpes (FR)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- The Journal of Allergy and Clinical Immunology In Practice
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jaip.2025.08.020
- Citations
- 3
- Primary Topic
- Pharmacy and Medical Practices
- Type
- article
- Field-Weighted Citation Impact
- 4.67