Enhanced insights into immunity traits of elderly patients in the intensive care unit with infections: evidence from a multicenter, prospective observational study
Elderly patients in the ICU, especially those with sepsis, exhibit immune imbalances of hyperinflammation and immunosuppression, varying with age, sex, pathogen type, and infection site. These findings highlight the potential role of immune phenotyping in guiding treatment decisions in this patient population.
Authors
- Xuelian Liao (ORCID: https://orcid.org/0000-0002-9121-0761)
- Xianwen Wang (ORCID: https://orcid.org/0000-0002-7236-9267)
- Na Cui (ORCID: https://orcid.org/0000-0003-1128-9228)
- Chunhui Li (ORCID: https://orcid.org/0000-0003-2418-5882)
- Ju Zou
- Yuanyuan Xiao (ORCID: https://orcid.org/0000-0003-0216-938X)
- Lina Zhang (ORCID: https://orcid.org/0000-0002-8214-8505)
- Anhua Wu (ORCID: https://orcid.org/0000-0003-2147-4582)
- Zhaoxin Qian (ORCID: https://orcid.org/0000-0002-2368-7840)
- Zhihong Zuo
- Jialin Jin
Institutions
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Peking Union Medical College Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Hunan Mawangdui Hospital (CN)
- National Clinical Research (US)
- Huashan Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s13054-025-05616-z
- Citations
- 4
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- China Railway
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University
- National Key Research and Development Program of China