Validation of pharmacokinetic model for quizartinib quantified by UPLC-MS/MS in patients with FLT3-ITD negative newly diagnosed acute myeloid leukemia
This study presents a replicable UPLC-MS/MS method for the determination of quizartinib in plasma. The validated popPK model can be used to optimize dosing strategies in future clinical studies.
Authors
- Pau Montesinos (ORCID: https://orcid.org/0000-0002-3275-5593)
- Rebeca Rodríguez‐Veiga (ORCID: https://orcid.org/0000-0003-2139-8540)
- Eva Barragán (ORCID: https://orcid.org/0000-0001-6735-0038)
- David Martínez‐Cuadrón (ORCID: https://orcid.org/0000-0001-7540-4091)
- M Gil Candel (ORCID: https://orcid.org/0000-0002-7398-8350)
- Juan Eduardo Megías‐Vericat (ORCID: https://orcid.org/0000-0002-0369-5341)
- Jorge Labrador (ORCID: https://orcid.org/0000-0002-3696-0287)
- Laura Torres-Miñana (ORCID: https://orcid.org/0009-0005-6930-8059)
- Isabel Cano‐Ferri
- Carles Iniesta Navalón (ORCID: https://orcid.org/0000-0002-3950-7250)
- Pilar Lloret Madrid (ORCID: https://orcid.org/0009-0003-6661-9631)
- Evelyn Acuña‐Cruz (ORCID: https://orcid.org/0000-0003-2869-369X)
- José‐Esteban Peris (ORCID: https://orcid.org/0000-0002-4811-239X)
- Blanca Boluda (ORCID: https://orcid.org/0000-0002-1785-5561)
- Antonio Solana‐Altabella (ORCID: https://orcid.org/0000-0002-8804-3878)
- Marina López‐Nogueroles (ORCID: https://orcid.org/0000-0003-3114-2231)
- Irene Navarro-Vicente
- José Luís Poveda (ORCID: https://orcid.org/0000-0003-1800-6198)
- José Vicente Gil (ORCID: https://orcid.org/0000-0003-2097-4796)
- Maria Choví-Trull (ORCID: https://orcid.org/0009-0000-3169-5253)
- Mario Rodenas-Rovira (ORCID: https://orcid.org/0000-0003-2256-3595)
Institutions
- Universitat de València (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital Universitario de Burgos (ES)
- Hospital Reina Sofía de Murcia (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- European Journal of Clinical Pharmacology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1007/s00228-025-03909-4
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Fundación para la Investigación del Hospital Universitari La Fe
- Instituto de Salud Carlos III