Atrial fibrillation and atherosclerosis cause different vascular brain lesions on magnetic resonance imaging
Patients with AF had a higher rate of non-lacunar infarcts, multi-infarct patterns and more severe periventricular white matter disease compared with patients with atherosclerosis. These findings support disease-specific mechanisms in the development of vascular brain lesions in patients with cardiovascular disease.
Authors
- Kelley R. Branch (ORCID: https://orcid.org/0000-0003-2362-6498)
- Philipp Krisai (ORCID: https://orcid.org/0000-0002-4367-2363)
- Peter Ammann (ORCID: https://orcid.org/0000-0002-2410-9807)
- Tina Stegmann (ORCID: https://orcid.org/0000-0002-9678-6196)
- Giorgio Moschovitis
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Eva Lonn (ORCID: https://orcid.org/0000-0002-0156-6730)
- Tim Sinnecker (ORCID: https://orcid.org/0000-0003-1508-318X)
- Marcello Di Valentino
- K. Reeh
- Jürg H. Beer (ORCID: https://orcid.org/0000-0002-7199-0406)
- Nicolas Rodondi (ORCID: https://orcid.org/0000-0001-9083-6896)
- Keith A.A. Fox (ORCID: https://orcid.org/0000-0002-0140-2752)
- Stefan Osswald (ORCID: https://orcid.org/0000-0002-9240-6731)
- Mukul Sharma (ORCID: https://orcid.org/0000-0002-6119-342X)
- Stefanie Aeschbacher (ORCID: https://orcid.org/0000-0001-8134-2421)
- Manuel R. Blum (ORCID: https://orcid.org/0000-0003-4638-775X)
- Michael Kühne (ORCID: https://orcid.org/0000-0002-2937-3711)
- Raed A. Joundi (ORCID: https://orcid.org/0000-0001-9554-0701)
- David Conen (ORCID: https://orcid.org/0000-0002-2459-5251)
- Abhilekh Srivastava
- Leo Hermann Bonati (ORCID: https://orcid.org/0000-0003-1163-8133)
- Jackie Bosch (ORCID: https://orcid.org/0000-0001-6292-4207)
- Álvaro Avezum (ORCID: https://orcid.org/0000-0002-3073-6890)
- Stuart J. Connolly (ORCID: https://orcid.org/0000-0002-7377-335X)
- John W. Eikelboom (ORCID: https://orcid.org/0000-0003-4126-1285)
- Rolf Wachter (ORCID: https://orcid.org/0000-0003-2231-2200)
- Tobias Reichlin (ORCID: https://orcid.org/0000-0002-7197-8415)
- Andreas S. Müller
- Qilong Yi
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- Allen Institute for Brain Science (US)
- University of Calgary (CA)
- University of Basel (CH)
- Kantonsspital St. Gallen (CH)
- Triemli Hospital (CH)
- University Hospital of Bern (CH)
- University of Washington Medical Center (US)
- University Hospital of Basel (CH)
- Population Health Research Institute (CA)
- Ospedale regionale di Lugano (CH)
- Hospital Base (CL)
- Ente Ospedaliero Cantonale (CH)
- University Hospital of Zurich (CH)
- University Hospital Leipzig (DE)
- Hope Heart Institute (US)
- Instituto Dante Pazzanese de Cardiologia (BR)
- Clinica Luganese Moncucco (CH)
- Hotchkiss Brain Institute (CA)
- Università della Svizzera italiana (CH)
- McMaster University (CA)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1093/eurheartj/ehaf550
- Citations
- 4
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Bayer
- Foundation for Cardiovascular Research
- Universität Basel
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung