A rare case of scleredema associated with breast cancer

SclerEDEMA is a rare condition marked by diffuse skin thickening, often confused with sclerODERMA. It is linked with infections, malignancies, and diabetes. Although scleredema is associated with hematologic malignancies like multiple myeloma, it has not been reported with breast cancer, as suspected in this patient. We present a case of a patient diagnosed with scleredema, confirmed through skin biopsy. Subsequent cancer screenings identified a 6 mm breast nodule, which was confirmed as grade 3 ductal carcinoma. This newfound association between scleredema and breast cancer highlights the importance of vigilant health maintenance and regular cancer screenings in these patients.

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Publication Details

Journal
Journal of Scleroderma and Related Disorders
Published
2025-08-30
DOI
https://doi.org/10.1177/23971983251370102
Primary Topic
Skin Diseases and Diabetes
Type
article
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article

A rare case of scleredema associated with breast cancer

Jenifer Centeno Gavica, Rupak Thapa
Journal of Scleroderma and Related Disorders
Skin Diseases and Diabetes
article

A rare case of scleredema associated with breast cancer

Jenifer Centeno Gavica, Rupak Thapa
article en

Abstract

SclerEDEMA is a rare condition marked by diffuse skin thickening, often confused with sclerODERMA. It is linked with infections, malignancies, and diabetes. Although scleredema is associated with hematologic malignancies like multiple myeloma, it has not been reported with breast cancer, as suspected in this patient. We present a case of a patient diagnosed with scleredema, confirmed through skin biopsy. Subsequent cancer screenings identified a 6 mm breast nodule, which was confirmed as grade 3 ductal carcinoma. This newfound association between scleredema and breast cancer highlights the importance of vigilant health maintenance and regular cancer screenings in these patients.

Journal of Scleroderma and Related DisordersVol. 10(3)
Atrium Health Wake Forest Baptist (US)
Openalex Percentile: Top 60%
Skin Diseases and Diabetes
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