Association between obstructive sleep apnea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease

Utilizing the gold-standard tools for OSA and NAFLD diagnosis in a multicentric cohort of biopsy-proven NAFLD patients, an independent association between OSA and liver fibrosis was confirmed. Statement of Significance This study provides the strongest evidence to date that obstructive sleep apnea (OSA) is independently associated with advanced liver fibrosis in patients with biopsy-proven NAFLD. Unlike prior studies based on indirect measures or bariatric populations, this work used gold-standard diagnostics-full polysomnography and liver histology-in a general NAFLD cohort. The high prevalence of OSA among patients with advanced fibrosis suggests systematic screening may be warranted. These findings identify OSA as a potential modifiable risk factor for liver disease progression.

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Publication Details

Journal
SLEEP
Published
2025-08-30
DOI
https://doi.org/10.1093/sleep/zsaf265
Citations
4
Primary Topic
Alcohol Consumption and Health Effects
Type
article
Field-Weighted Citation Impact
5.89
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article

Association between obstructive sleep apnea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease

Maéva Guillaume, Charlotte E. Costentin, S. Pontier, Matthieu Schnee et al.
4 citations
SLEEP
Alcohol Consumption and Health Effects
5.89
article

Association between obstructive sleep apnea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease

Maéva Guillaume, Charlotte E. Costentin, S. Pontier, Matthieu Schnee, K. Sedkaoui, A. Bizieux, Jérôme Boursier, Jean‐Louis Pépin, Christophe Bureau, Wojciech Trzépizur, Frédéric Gagnadoux, Jérémie Poilane, Jean-François Hamel
article en
4 citations

Abstract

Utilizing the gold-standard tools for OSA and NAFLD diagnosis in a multicentric cohort of biopsy-proven NAFLD patients, an independent association between OSA and liver fibrosis was confirmed. Statement of Significance This study provides the strongest evidence to date that obstructive sleep apnea (OSA) is independently associated with advanced liver fibrosis in patients with biopsy-proven NAFLD. Unlike prior studies based on indirect measures or bariatric populations, this work used gold-standard diagnostics-full polysomnography and liver histology-in a general NAFLD cohort. The high prevalence of OSA among patients with advanced fibrosis suggests systematic screening may be warranted. These findings identify OSA as a potential modifiable risk factor for liver disease progression.

SLEEPVol. 49(2)
Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Inserm (FR), Centre Hospitalier Universitaire de Grenoble (FR), Centre Hospitalier Universitaire de Toulouse (FR), Hôpital Rangueil (FR), Hôpital Larrey (FR), Clinique Pasteur (FR), Centre Hospitalier Départemental Vendée (FR), Grenoble Institute of Neurosciences (FR), Université d'Angers (FR), Université Grenoble Alpes (FR)
Openalex Percentile: Top 4%
Alcohol Consumption and Health Effects
5.89
DOISourceOpenAlex
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