Age at disease onset and risk of chronic kidney disease in patients with heterozygous disease-causing variants in <i>COL4A3</i> and <i>COL4A4</i>
Earlier onset of disease may predict higher risk of CKD in patients with heterozygous disease-causing <i>COL4A3/4</i> variants. This association, if verified in large prospective studies, may help stratify patients by risk of worse prognosis, which can guide their management and preemptive nephroprotective treatment.
Authors
- Guangyi Liu
- Fujun Lin (ORCID: https://orcid.org/0000-0002-1887-545X)
- Shu‐Feng Zhou (ORCID: https://orcid.org/0000-0002-7215-707X)
- Ying Fan (ORCID: https://orcid.org/0000-0002-2532-9254)
- Ning Yang (ORCID: https://orcid.org/0000-0001-5121-7208)
- Wenyan Huang (ORCID: https://orcid.org/0000-0002-2197-0781)
- Xin Sun (ORCID: https://orcid.org/0000-0003-0864-9085)
- Gengru Jiang (ORCID: https://orcid.org/0000-0002-4211-4271)
- Yi Fang (ORCID: https://orcid.org/0000-0001-8675-4513)
- Shi Jin (ORCID: https://orcid.org/0000-0001-5160-5403)
- Bixia Zheng (ORCID: https://orcid.org/0000-0003-3457-6545)
- Zhangzhe Peng (ORCID: https://orcid.org/0000-0003-4707-2776)
- Jia Rao (ORCID: https://orcid.org/0000-0003-2839-3419)
- Yu Sun (ORCID: https://orcid.org/0000-0002-6666-8586)
- Xuantong Dai
- Xi Zhang (ORCID: https://orcid.org/0000-0001-9369-0060)
- Jiawei Yu (ORCID: https://orcid.org/0009-0005-9793-1067)
- Ziyi Zhao (ORCID: https://orcid.org/0000-0002-0818-7661)
- Lei Sun (ORCID: https://orcid.org/0000-0001-6000-5864)
- Ningning Hu
- Xialian Xu (ORCID: https://orcid.org/0000-0003-0598-2149)
- Yiqin Shi (ORCID: https://orcid.org/0000-0001-5436-9100)
- Mingzhu Zhao
- Qi Bian (ORCID: https://orcid.org/0000-0002-5440-9333)
- Lirong Lin
- Jia Chen (ORCID: https://orcid.org/0009-0009-4310-4428)
Institutions
- Central South University (CN)
- Army Medical University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Dalian Medical University (CN)
- Peking University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Nanjing Children's Hospital (CN)
- Daping Hospital (CN)
- Changhai Hospital (CN)
- Third People 's Hospital of Chongqing (CN)
- Zhongshan Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Qilu Hospital of Shandong University (CN)
- Nanjing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1093/ckj/sfaf272
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University