Diagnostic Value of Relative Flow Reserve in Patients With Prior Coronary Artery Disease: A Post Hoc Analysis of the PACIFIC-2 Trial
RFR proves clinically applicable, even without specific patient selection and knowledge of the coronary anatomy. However, RFR does not outperform absolute hyperemic myocardial perfusion for detecting FFR-defined significant CAD in patients with prior CAD and recurrence of symptoms.
Authors
- Paul Knaapen (ORCID: https://orcid.org/0000-0001-8038-7898)
- Ruurt Jukema (ORCID: https://orcid.org/0000-0002-3212-2665)
- Yvemarie Somsen (ORCID: https://orcid.org/0009-0002-2585-9631)
- Roel Hoek (ORCID: https://orcid.org/0000-0002-7927-0366)
- Ibrahim Danad (ORCID: https://orcid.org/0000-0002-3140-1320)
- Jos W. R. Twisk (ORCID: https://orcid.org/0000-0001-9617-1020)
- Ruben W. de Winter (ORCID: https://orcid.org/0000-0003-2199-5943)
- Juhani Knuuti (ORCID: https://orcid.org/0000-0003-3156-9593)
- Roel S. Driessen (ORCID: https://orcid.org/0000-0003-3971-0109)
- Pieter G. Raijmakers (ORCID: https://orcid.org/0000-0002-5225-3240)
- Pepijn A. van Diemen (ORCID: https://orcid.org/0000-0001-5482-6201)
Institutions
- Radboud University Nijmegen (NL)
- Turku University Hospital (FI)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Northwest Hospital (US)
- Turku PET Centre (FI)
- Radboud Institute for Molecular Life Sciences (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1161/circimaging.125.018574
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00