Exogenous α-linolenic acid acts as a negative regulator of <i>Cronobacter sakazakii</i> structural flagellar proteins
Antimicrobial lipids, such as fatty acids, are reported to act as regulatory molecules, capable of modulating virulence factors in Gram-negative pathogens such as Cholera and Salmonella species. Through proteomic analysis, RT-qPCR and functional assays, the results indicate that ALA negatively regulates flagellar genes, resulting in reduced expression of structural proteins and subsequent loss of motility.
Authors
- Carmel Kealey (ORCID: https://orcid.org/0000-0003-4979-6241)
- Katie Phair (ORCID: https://orcid.org/0000-0003-2815-4653)
- Aaron Curtis (ORCID: https://orcid.org/0000-0003-4375-8391)
- D. Brady (ORCID: https://orcid.org/0000-0002-3648-3302)
- Kevin Kavanagh (ORCID: https://orcid.org/0000-0003-3186-0292)
Institutions
- National University of Ireland, Maynooth (IE)
- University of the West (US)
- Institute of Technology Carlow (IE)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1093/jambio/lxaf218
- Primary Topic
- Enterobacteriaceae and Cronobacter Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science Foundation Ireland
- Irish Research Council