Mining and Analysis on the Medication Rules of Traditional Chinese Medicine for Insomnia

Objective To explore the medication rule of traditional Chinese medicines (also called herbs) in treating insomnia, and to provide a reference for clinical treatment and scientific research. Methods Taking the Ancient and Modern Medical Record Cloud Platform (https://www.yiankb.com) as the data source, with the subject terms of "insomnia", "sleeplessness", etc., we screened out the cases of Chinese medicine treatment of insomnia from the modern famous doctors' database and the modern medical database, extracted the prescription information in the cases meeting the criteria, and entered them into Excel. Then SPSS Modeler 18.0 was used to perform association rule analysis and association network diagram drawing, and SPSS Statistics 27.0 was used to perform cluster analysis of high-frequency drugs. Results A total of 363 medical records were retrieved, and 193 cases that met the inclusion criteria were screened. Statistical results showed that among 193 cases for treatment of insomnia, the most frequently used herbs were Suan Zao Ren (104 times, 53.89%), Poria cocos (79 times, 40.93%), and Radix angelicae sinensis (65 times, 33.68%); in terms of drug efficacy, tonic herbs (562 times, 27.5%), tranquilizers (328, 16.05%), and heat-clearing herbs (237, 11.59%) were used most frequently; the heart meridian was the most commonly used meridian, and the most frequently used medicinal properties and flavors were neutral nature and sweet flavor. Conclusion Among the cases from modern famous and old TCM doctors and cases from modern medical database included in the Ancient and Modern Medical Record Cloud Platform: the main herbs for treating insomnia include Suan Zao Ren, Poria cocos, Radix angelicae sinensis, Radix glycyrrhizae, Radix bupleuri, Radix paeoniae alba, Radix rehmanniae, and Radix polygalae; the most strongly associated herb pairs are Suan Zao Ren - Schisandrae fructus, Concha ostreae - Os draconis, and Suan Zao Ren - Radix astragali.