Differential chemokine profiles between lacrimal and salivary glands in a murine model of primary Sjögren disease
These findings suggest that CXCL4-producing macrophages may promote the recruitment of CXCR3<sup>+</sup> Th1 cells into the LGs in pSjD, thereby contributing to LG-specific autoimmune inflammation. This mechanism may represent a potential therapeutic target for managing dry eye in pSjD.
Authors
- Naozumi Ishimaru (ORCID: https://orcid.org/0000-0003-1087-8338)
- Kunihiro Otsuka (ORCID: https://orcid.org/0000-0002-3546-8143)
- Takaaki Tsunematsu (ORCID: https://orcid.org/0000-0003-1043-2790)
- Shigefumi Matsuzawa
- Ruka Nagao
- Aya Ushio (ORCID: https://orcid.org/0009-0008-3786-1687)
Institutions
- Tokyo Medical and Dental University (JP)
- Kyushu University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Cytokine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.cyto.2025.157023
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency