PPIL1 Drives Hepatocellular Carcinoma Progression and Cancer Stem Cell Self-renewal Through DAAM2-mediated Wnt/β-Catenin Activation
Our findings suggest PPIL1 to be a crucial regulator of HCC progression and liver CSC maintenance <i>via</i> DAAM2-mediated Wnt/β-catenin activation. This positions PPIL1 as a promising molecular target for HCC therapy, with particular relevance for addressing CSC-driven therapeutic resistance.
Authors
- Yu Qi (ORCID: https://orcid.org/0000-0002-0638-2594)
- Jiayi Wu (ORCID: https://orcid.org/0009-0001-9291-0399)
- Sung Pil Chang
- Wen-Pin Su
- Shuo Chen (ORCID: https://orcid.org/0000-0002-0678-7380)
Institutions
- Nankai University (CN)
- Zhengzhou University (CN)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.21873/cgp.20535
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Natural Science Foundation of Tianjin City