Identification of <i>CXCL8, IL1A</i>, and <i>IL1B</i> as Hub Genes of Therapeutic Resistance in Glioblastoma Multiforme <i>via</i> Bioinformatics Analysis
This study identifies <i>CXCL8, IL1A</i>, and <i>IL1B</i> as potential therapeutic targets for overcoming the resistance of GBM to radiotherapy and chemotherapy. In addition, these genes might serve as prognostic biomarkers and key regulators of GBM malignancy. Future studies are warranted to explore their functional roles <i>in vivo</i> and assess their potential use as therapeutic intervention targets.
Authors
- BuHyun Youn (ORCID: https://orcid.org/0000-0002-8010-519X)
- Jungwook Roh (ORCID: https://orcid.org/0000-0003-0298-195X)
- Wanyeon Kim (ORCID: https://orcid.org/0000-0002-7611-5248)
- Jie Kang (ORCID: https://orcid.org/0000-0001-5413-2648)
- S. Lee (ORCID: https://orcid.org/0000-0001-8614-6753)
- Grace Yoon (ORCID: https://orcid.org/0000-0002-0415-4416)
Institutions
- Korea National University of Education (KR)
- Seowon University (KR)
- Yeungnam University College
- Yeungnam University (KR)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.21873/cgp.20537
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80