Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia
SETD8 increases enhancer chromatin accessibility and expression of RHOT1 to reprogram mitochondrial homeostasis and support leukemia stem cells, indicating that SETD8 may be a druggable target for acute myeloid leukemia.
Authors
- Yongwei Su (ORCID: https://orcid.org/0009-0008-3354-1811)
- Shuyi Li (ORCID: https://orcid.org/0009-0005-8949-3167)
- Jingqiao Qiao (ORCID: https://orcid.org/0009-0000-1877-0044)
- Xiaotong Li (ORCID: https://orcid.org/0009-0004-8753-4183)
- Jingfeng Zhou (ORCID: https://orcid.org/0000-0002-4415-3848)
- Li Yu (ORCID: https://orcid.org/0000-0001-6872-2665)
- Shujiao He (ORCID: https://orcid.org/0000-0003-3128-2541)
- Yiran Wang (ORCID: https://orcid.org/0009-0001-9618-4371)
- Lei Wang (ORCID: https://orcid.org/0000-0003-1028-3334)
Institutions
- Shenzhen University (CN)
- Jilin University (CN)
- Jilin Medical University (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3659
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77