MYADM Activates RhoA-Mediated Ameboid Migration to Drive Metastasis
Targeting MYADM, which interacts with RhoGDI to induce RhoA-driven amoeboid migration plasticity and chromatin dynamics, is a strategy to block metastatic progression that selectively impairs cancer cell survival.
Authors
- Mong‐Hsun Tsai (ORCID: https://orcid.org/0000-0001-8777-5818)
- Pei‐Wen Hsiao (ORCID: https://orcid.org/0000-0002-3589-6754)
- En-Ting Liu (ORCID: https://orcid.org/0009-0007-7993-690X)
- Grace S. Shieh (ORCID: https://orcid.org/0000-0001-7646-6753)
- Chin Li Chen (ORCID: https://orcid.org/0000-0002-0052-0204)
- Yi-Ta Tsai (ORCID: https://orcid.org/0009-0002-9154-9914)
- An‐Chieh Feng (ORCID: https://orcid.org/0000-0002-0946-8131)
- Wen‐Chiuan Tsai (ORCID: https://orcid.org/0000-0003-1085-9014)
- Shau‐Kwaun Chen (ORCID: https://orcid.org/0000-0002-0701-6799)
- Sheue‐Fen Tzeng (ORCID: https://orcid.org/0000-0003-1126-6763)
- Chien‐Chang Kao (ORCID: https://orcid.org/0000-0003-0107-4450)
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
- En Meng (ORCID: https://orcid.org/0000-0002-1262-5361)
- Yi‐Lin Chiu (ORCID: https://orcid.org/0000-0002-1827-6924)
- Tai‐Kuang Chao (ORCID: https://orcid.org/0000-0001-8219-6382)
- Yu-Chi Chen (ORCID: https://orcid.org/0009-0001-9591-1311)
- Sheng‐Tang Wu (ORCID: https://orcid.org/0000-0002-4487-1575)
- Ming‐Hsin Yang (ORCID: https://orcid.org/0009-0008-6433-7207)
- Guang-Huan Sun (ORCID: https://orcid.org/0000-0002-4162-7411)
- Sun‐Yran Chang (ORCID: https://orcid.org/0009-0007-6740-8405)
- Tai‐Lung Cha (ORCID: https://orcid.org/0000-0003-3569-771X)
Institutions
- Tri-Service General Hospital (TW)
- National Health Research Institutes (TW)
- National Taiwan University (TW)
- China Medical University (TW)
- Tzu Chi Foundation (TW)
- Genomics Research Center, Academia Sinica (TW)
- E-Da Hospital (TW)
- Taipei Hospital (TW)
- Institute of Statistical Science, Academia Sinica (TW)
- Buddhist Tzu Chi Medical Foundation (US)
- Taipei Institute of Pathology (TW)
- Agricultural Biotechnology Research Center, Academia Sinica (TW)
- National Defence Medical Centre (CA)
- National Defense Medical Center (TW)
- Academia Sinica (TW)
- National Chengchi University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0006
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00