Prognostic Value of Programmed Cell Death Ligand 1 (PD-L1) Expression in Patients With Papillary Thyroid Carcinoma: A Retrospective Biomarker Study

PD-L1 expression was present in nearly half of this real-world Greek PTC cohort and was associated with multiple adverse clinicopathological features and an increased risk of recurrence. These findings support the potential utility of PD-L1 as a prognostic biomarker in PTC and may inform postoperative risk stratification and follow-up strategies, although further prospective studies in larger, multicenter cohorts are warranted to corroborate these results.

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Publication Details

Journal
Cureus
Published
2025-08-30
DOI
https://doi.org/10.7759/cureus.91281
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
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article

Prognostic Value of Programmed Cell Death Ligand 1 (PD-L1) Expression in Patients With Papillary Thyroid Carcinoma: A Retrospective Biomarker Study

E. Nikolaou, Dimitrios Theodosiou, Dimitrios Lefantzis, Pavlos Maragkoudakis et al.
Cureus
Thyroid Cancer Diagnosis and Treatment
article

Prognostic Value of Programmed Cell Death Ligand 1 (PD-L1) Expression in Patients With Papillary Thyroid Carcinoma: A Retrospective Biomarker Study

E. Nikolaou, Dimitrios Theodosiou, Dimitrios Lefantzis, Pavlos Maragkoudakis, Spyridon Lygeros, Stylianos Triantos, Vassilis Samaras, Dimitra Spyroulia
article en

Abstract

PD-L1 expression was present in nearly half of this real-world Greek PTC cohort and was associated with multiple adverse clinicopathological features and an increased risk of recurrence. These findings support the potential utility of PD-L1 as a prognostic biomarker in PTC and may inform postoperative risk stratification and follow-up strategies, although further prospective studies in larger, multicenter cohorts are warranted to corroborate these results.

CureusVol. 17(8)
National and Kapodistrian University of Athens (GR), General University Hospital of Patras (GR), Hellenic Red Cross (GR), Kalgoorlie Consolidated Gold Mines (Australia) (AU)
Good health and well-being
Openalex Percentile: Top 69%
Thyroid Cancer Diagnosis and Treatment
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