Two‐Year Turning Point With Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Control, Remission, and Tapering Dosage
This is the largest real-life study evaluating dupilumab in CRSwNP over 2 years. Dupilumab showed sustained effectiveness, with progressive improvements across all clinical outcomes. Dupilumab tapering did not compromise outcomes; treatment continuation allowed meaningful clinical benefits in late responders. Two-year rates of disease control and remission are clinically relevant, although standardized criteria to assess these outcomes are needed.
Authors
- Antonella Loperfido (ORCID: https://orcid.org/0000-0002-7174-8126)
- Marco Corbò (ORCID: https://orcid.org/0009-0005-7394-8630)
- Giuseppe D’Agostino (ORCID: https://orcid.org/0000-0002-2518-3435)
- Giancarlo Ottaviano (ORCID: https://orcid.org/0000-0003-2433-4761)
- Massimiliano Garzaro (ORCID: https://orcid.org/0000-0001-9949-1177)
- Sara Torretta (ORCID: https://orcid.org/0000-0002-8461-6042)
- Daniela Lucidi (ORCID: https://orcid.org/0000-0003-3341-5926)
- Claudio Montuori (ORCID: https://orcid.org/0000-0003-2070-0314)
- Elena Cantone (ORCID: https://orcid.org/0000-0002-7389-2033)
- Giulia Danè (ORCID: https://orcid.org/0009-0003-7905-7260)
- Ernesto Pasquini (ORCID: https://orcid.org/0000-0001-8480-0387)
- Veronica Seccia (ORCID: https://orcid.org/0000-0002-6297-8034)
- L. D’Auria (ORCID: https://orcid.org/0009-0007-7101-1080)
- Francesca Anastasi (ORCID: https://orcid.org/0000-0002-6566-6909)
- Eugenio De Corso (ORCID: https://orcid.org/0000-0001-5761-7018)
- Francesco Bussu (ORCID: https://orcid.org/0000-0001-6261-2772)
- Angelo Ghidini (ORCID: https://orcid.org/0000-0002-4117-1901)
- Gian Luca Fadda (ORCID: https://orcid.org/0000-0001-8111-7291)
- Jacopo Galli (ORCID: https://orcid.org/0000-0003-1599-4573)
- Giulio Pagliuca (ORCID: https://orcid.org/0000-0002-2845-4931)
- Carlo Cavaliere (ORCID: https://orcid.org/0000-0002-0378-8935)
- Fabio Pagella (ORCID: https://orcid.org/0000-0002-2244-373X)
- Carlotta Pipolo (ORCID: https://orcid.org/0000-0001-6628-2117)
- Frank Rikki Canevari (ORCID: https://orcid.org/0000-0002-1821-7262)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Marianna Maffei (ORCID: https://orcid.org/0000-0001-8825-5048)
- Ignazio La Mantia (ORCID: https://orcid.org/0000-0002-7155-273X)
- Gabriele De Maio (ORCID: https://orcid.org/0009-0000-1985-8224)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- AOL (United States) (US)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Sassari (IT)
- University of Pavia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Catania (IT)
- Nuovo Ospedale San Giovanni di Dio (IT)
- Azienda Ospedaliero Universitaria di Sassari (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Ospedale Santa Maria (IT)
- Federico II University Hospital (IT)
- Azienda USL di Bologna (IT)
- Ospedale Santa Maria Goretti (IT)
- Ospedale Policlinico San Martino (IT)
- Ospedale D. Cotugno (IT)
- Fondazione Audiologica Varese (IT)
- University of the Sacred Heart (JP)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ospedale San Luigi Gonzaga (IT)
- Piedmont University (US)
- American Association for the Surgery of Trauma (US)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Allergy
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1111/all.70032
- Citations
- 4
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 7.39