Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones
A tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes under photoinduced reaction conditions was developed to synthesize ring-fused quinazolinones for the first time. The concise, mild and photocatalyst- and oxidant-free conditions, as well as the good functional group tolerance, render this protocol a green and convenient strategy for synthesizing polycyclic ring-fused quinazolinones. Mechanistic studies indicated that the process might involve a radical pathway.
Authors
- Jie Kang (ORCID: https://orcid.org/0000-0002-8991-2844)
- Kui Lu (ORCID: https://orcid.org/0000-0002-9685-2691)
- Haijuan Qin (ORCID: https://orcid.org/0009-0007-1648-7844)
- Xia Zhao (ORCID: https://orcid.org/0000-0001-9477-5912)
- Mengfei Yang
- Xi Chen (ORCID: https://orcid.org/0000-0001-7303-148X)
- Jing Liu (ORCID: https://orcid.org/0000-0002-8740-4600)
Institutions
- Tianjin University of Science and Technology (CN)
- Tianjin Normal University (CN)
- China International Science and Technology Cooperation (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01287b
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00