Synthesis of biologically active heterocyclic compounds from β-diketones

This review focuses on the design, synthesis, and biological evaluation of novel heterocyclic compounds derived from -diketones and cyanomethylene reagents through multicomponent and green synthetic methodologies.The study encompasses a wide range of heterocyclic scaffolds, including xanthene, chromene, chromenone, coumarin, acridine, quinoline, thiazole, thiophene, and spiro-heterocycles containing nitrogen, oxygen, and sulfur.A variety of catalysts were employed such as DBSA, P-TSA, NbCl, and nano-magnetic composites like CuFeO/chitosan to optimize reaction conditions for eco-friendly and high-yielding transformations.The developed synthetic strategies included one-pot, microwave-assisted, and solvent-free techniques, resulting in efficient routes to complex molecular architectures.The biological activity of the synthesized compounds was extensively screened, with several candidates exhibiting promising antimicrobial, antifungal, anticancer, and kinase-inhibitory properties.Structure-activity relationship (SAR) studies indicated that specific heteroatom substitutions enhanced biological potency, particularly in xanthene and chromenoquinoline derivatives.This work contributes to advancing heterocyclic chemistry by introducing new reaction pathways, novel molecular frameworks, and bioactive agents with potential pharmaceutical applications.